The male contraceptive pill It is one of those challenges of science for which effort is made, but just. After all, there is already one for women. It doesn’t matter that many have to deal with the side effects of a constant hormone boost. There is time to get the perfect pill for men. One that prevents them from getting their partners pregnant, but with the minimum possible side effects. Some clinical trials have already been done with hormonal pills; But, as is the case with women, Adverse effects there have been quite a few. In some cases, it must be admitted that they have been terrifying. For this reason, steps have been taken and none of these drugs have been marketed. Now, finally, a male contraceptive pill that does not use hormones has reached the phase of clinical trials.
It had previously been tested on mice, with very good results. For this reason, a first phase of clinical trials in humans has been started, which is expected to be completed. in mid-2024. If all goes well, we will have to continue climbing and, finally, obtain the necessary permits for its commercialization.
All this indicates that there are still several years ahead until the male contraceptive pill becomes a reality. Meanwhile, men can only use condoms or have a vasectomy. Women will continue to be the ones carrying the hormones.
Clinical trials that were canceled
These are the first clinical trials of a male contraceptive pill hormone free. In the past, clinical trials have been carried out with hormonal drugs. But the side effects were so intense that they were cancelled.
Most were at skin level, especially with a large number of acne cases. However, there were also humor changessome of which became so intense that they ended in suicide attempts.
In women, it has been thought that something similar could happen. However, later studies have been carried out that have denied that there was anything more than a casual correlation. In the case of the male contraceptive pill, it was not delved into whether it had been a coincidence. It was considered an adverse effect large enough to stop clinical trials.
Now, a new drug, called YCT-529is also beginning to take the path of clinical trials, but this time without hormones in the equation.
How does this male contraceptive pill work?
YCT-529 is a male contraceptive pill that acts by inhibiting the alpha retinoic acid receptor. Retinoic acid is a derivative of vitamin A, which is essential for the sperm synthesis. But, in order for it to perform its function, it must first bind to its recipient. If the receptor is inhibited, as if we insert a wire into a lock, retinoic acid cannot insert the key and sperm are not synthesized.
In studies with mice, it has been observed that pregnancy is prevented with an effectiveness of 99%. Furthermore, there are hardly any side effects and the effect is completely reversible. Once you stop taking the male contraceptive pill, sperm could be synthesized again without problem. The wire comes out of the lock.
As is usual in the first phase of clinical trials of any drug, very few people will participate. Specifically, two cohorts of 8 volunteers each. With them, the effectiveness will be analyzed, but above all the safety and tolerability of YCT-529.
If all goes well, new phases of clinical trials will be promoted, in which more volunteers will participate and the dosage, effects and proper functioning of this male contraceptive pill will be much more outlined. Step by Step. Time will tell if we have finally reached the definitive drug.