Acne is a major problem during adolescence and late adolescence.
Acne is very common, although there are extreme cases that are truly problematic, many of us have had to deal in our adolescence, youth and even adulthood with this problem that It has become very annoying and whose treatments could be quite invasive and not worth it. There are even applications designed to hide our pimples in the photographs we take, since for many people it can cause a strong self-esteem problem and mark their social relationships.
Our skin is the result of millions of years of evolution and has adapted, but problems have also arisen that need to be solved. Among them acne, but why does it happen?
Why acne occurs
Acne is one of the most common skin conditions and has a well-known origin caused by the clogging of hair follicles due to the accumulation of dead cells and oils, causing inflammation and the subsequent appearance of pimples. These rashes, of different types: blackheads, whiteheads, or directly inflammation on the specific part of the face, usually cause problems later by leaving marks on those people who exploit them or because they explode on their own and do not heal well
With the aim of searching for effective solutions, a scientific team from Pompeu Fabra University has published a promising article in Nature directed by Nastassia Knödlseder and María José Fábrega. In it, they have worked with natural bacteria of our skin as the Cutibacterium acnes with the aim of generating a protein that allows us to combat this issue.
A study that could change everything
Through a process of bacterial engineering, they have transformed the Cutibacterium acnes so that it is capable of producing the NGAL protein, which plays a crucial role in reducing sebum production, a determining factor in the formation of acne. This promises a solution to the problem since it intervenes directly in the biological process of acne formation without the need to apply products to the skin or take any type of oral medication. In the words of Nastassia Knödlseder:
We have designed a bacteria that lives on the skin and produces what our skin needs.
The first trials of this technology, carried out both in mice and in human skin cell cultures, have shown promising results. However, given the notable difference between mouse and human skin, these results are preliminary, and not conclusive. Therefore, further research will be necessary to achieve greater knowledge of whether this treatment is successful. To do this, they will begin to investigate 3D human skin models.
Thus, a path is marked quite interesting regarding the investigation of the bacteria engineeringsomething that until now was typical of the best science fiction stories.
- Acne is caused by the accumulation of dead cells and oils in the hair follicles of our face, which inflames them and causes pimples to appear.
- A scientific team from the Pompeu Fabra University has managed to engineer bacteria that live on the skin to produce anti-acne proteins.
- They have modified the Cutibacterium acnes typical of our skin to create the necessary ingredients to eliminate pimples.
- Now it is capable of producing NGAL protein, significantly reducing the appearance of sebum that causes acne.
- So far, it has been successfully tested in mice and in human skin cell cultures.
- This makes the results inconclusive since mice have very different skin from humans, further research will be necessary.
- The goal is to continue researching with 3D skin models.
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